White matter microstructure predicts cognitive training-induced improvements in attention and executive functioning in schizophrenia.

ABSTRACT: We examined the relationship between white matter microstructure in schizophrenia using diffusion tensor imaging (DTI) and cognitive improvements induced by 70h (~16weeks) of cognitive training. We measured anatomical connectivity in 48 patients with schizophrenia (SZ) and 28 healthy control participants (HC) at baseline, and then examined the relationship between anatomical connectivity at baseline and training-induced cognitive gains in 30 SZ who performed diffusion imaging after completing 70h of training. Compared with healthy control participants, individuals with schizophrenia showed reduced white matter integrity at baseline, as indexed by fractional anisotropy metrics, in bilateral posterior corona radiata, bilateral retrolenticular internal capsules, bilateral posterior thalamic r

SUBMITTER: Subramaniam K 

PROVIDER: S-EPMC5999406 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature