Monocyte Function and Clinical Outcomes in Febrile and Afebrile Patients With Severe Sepsis.

ABSTRACT:

Introduction

Absence of fever is associated with higher mortality in septic patients, but the reason for this is unknown. Immune dysfunction may be a potential link between failure to mount a fever and poor outcomes. The purpose of this study was to evaluate monocyte function and clinical surrogates of immunity (i.e., mortality and acquisition of secondary infections) in febrile and afebrile septic patients.

Methods

Single-center, prospective cohort study of 92 critically ill septic patients. Patients were categorized into febrile (≥38.0°C) and afebrile (<38.0°C) groups based on temperature measurements within 24 hours of sepsis diagnosis. HLA-DR expression and LPS-induced TNF-α production were quantified on days 1-2, days 3-4, and days 6-8 after sepsis diagnosis. A repeated

SUBMITTER: Drewry AM 

PROVIDER: S-EPMC5999533 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature