Roux-en-Y gastric bypass compared with equivalent diet restriction: Mechanistic insights into diabetes remission.

ABSTRACT: AIMS:To investigate the physiological mechanisms leading to rapid improvement in diabetes after Roux-en-Y gastric bypass (RYGB) and specifically the contribution of the concurrent peri-operative dietary restrictions, which may also alter glucose metabolism. MATERIALS AND METHODS:In order to assess the differential contributions of diet and surgery to the mechanisms leading to the rapid improvement in diabetes after RYGB we enrolled 10 patients with type 2 diabetes scheduled to undergo RYGB. All patients underwent a 10-day inpatient supervised dietary intervention equivalent to the peri-operative diet (diet-only period), followed by, after a re-equilibration (washout) period, an identical period of pair-matched diet in conjunction with RYGB (diet and RYGB period). We conducted extensive met

SUBMITTER: Pop LM 

PROVIDER: S-EPMC5999551 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature