Comparison of ¹⁸F-T807 and ¹⁸F-THK5117 PET in a Mouse Model of Tau Pathology.

ABSTRACT: Positron-emission-tomography (PET) imaging of tau pathology has facilitated development of anti-tau therapies. While members of the arylquinoline and pyridoindole families have been the most frequently used tau radioligands so far, analyses of their comparative performance in vivo are scantly documented. Here, we conducted a head-to-head PET comparison of the arylquinoline ¹⁸FT807 and the pyridoindole ¹⁸FTHK5117 PET in a mouse model of tau pathology. PET recordings were obtained in groups of (N = 5-7) P301S and wild-type (WT) mice at 6 and 9 months of age. Volume-of-interest based analysis (standard-uptake-value ratio, SUVR) was used to calculate effect sizes (Cohen's d) for each tracer and age. Statistical parametric mapping (SPM) was used to ass

SUBMITTER: Brendel M 

PROVIDER: S-EPMC5999706 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature