The Notch Signaling Pathway Is Balancing Type 1 Innate Lymphoid Cell Immune Functions.

ABSTRACT: The Notch pathway is one of the canonical signaling pathways implicated in the development of various solid tumors. During carcinogenesis, the Notch pathway dysregulation induces tumor expression of Notch receptor ligands participating to escape the immune surveillance. The Notch pathway conditions both the development and the functional regulation of lymphoid subsets. Its importance on T cell subset polarization has been documented contrary to its action on innate lymphoid cells (ILC). We aim to analyze the effect of the Notch pathway on type 1 ILC polarization and functions after disruption of the RBPJk-dependent Notch signaling cascade. Indeed, type 1 ILC comprises conventional NK (cNK) cells and type 1 helper innate lymphoid cells (ILC1) that share Notch-related functional characterist

SUBMITTER: Perchet T 

PROVIDER: S-EPMC5999736 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature