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Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β⁺ T Cells and Differentiated γδ T Cells Alongside a Regulatory Response Mediated by FOXP3⁺ T Cells and Immunoregulatory Molecules.

ABSTRACT: In recent years, immunotherapy has shown considerable promise in the management of several malignancies. However, the majority of preclinical studies have been conducted in rodents, the results of which often translate poorly to patients given the substantial differences between murine and human immunology. As the porcine immune system is far more analogous to that of humans, pigs may serve as a supplementary preclinical model for future testing of such therapies. We have generated the genetically modified Oncopig with inducible tumor formation resulting from concomitant KRAS^G12D and TP53^R167H mutations under control of an adenoviral vector Cre-recombinase (AdCre). The objective of this study was to characterize the tumor microenvironment in this novel a

SUBMITTER: Overgaard NH

PROVIDER: S-EPMC5999797 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Dataset Information

Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β⁺ T Cells and Differentiated γδ T Cells Alongside a Regulatory Response Mediated by FOXP3⁺ T Cells and Immunoregulatory Molecules.

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Dataset Information

Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β+ T Cells and Differentiated γδ T Cells Alongside a Regulatory Response Mediated by FOXP3+ T Cells and Immunoregulatory Molecules.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β⁺ T Cells and Differentiated γδ T Cells Alongside a Regulatory Response Mediated by FOXP3⁺ T Cells and Immunoregulatory Molecules.