Proscillaridin A induces apoptosis and suppresses non-small-cell lung cancer tumor growth via calcium-induced DR4 upregulation.

ABSTRACT: Non-small-cell lung cancer (NSCLC) is the predominant histological type of lung cancer and is characterized by the highest mortality and incidence rates among these types of malignancies. Cardiac glycosides, a class of natural products, have been identified as a potential type of chemotherapeutic agent. This study aims to investigate the anti-cancer effects and the mechanisms of action of Proscillaridin A (P.A) in NSCLC cells. In vitro sodium-potassium pump (Na⁺/K⁺ ATPase) enzyme assays indicated that P.A is a direct Na⁺/K⁺ ATPase inhibitor. P.A showed potent cytotoxic effects in NSCLC cells at nanomolar levels. Treatment mechanism studies indicated that P.A elevated Ca²⁺ levels, activated the AMPK pathway and downregulated phosphoryla

SUBMITTER: Li RZ 

PROVIDER: S-EPMC5999972 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature