Neuronal and non-neuronal signals regulate Caernorhabditis elegans avoidance of contaminated food.

ABSTRACT: One way in which animals minimize the risk of infection is to reduce their contact with contaminated food. Here, we establish a model of pathogen-contaminated food avoidance using the nematode worm Caernorhabditis elegans We find that avoidance of pathogen-contaminated food protects C. elegans from the deleterious effects of infection and, using genetic approaches, demonstrate that multiple sensory neurons are required for this avoidance behaviour. In addition, our results reveal that the avoidance of contaminated food requires bacterial adherence to non-neuronal cells in the tail of C. elegans that are also required for the cellular immune response. Previous studies in C. elegans have contributed significantly to our understanding of molecular and cellular basis of host-pathogen interacti

SUBMITTER: Anderson A 

PROVIDER: S-EPMC6000145 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature