Noise-induced bistability in the quasi-neutral coexistence of viral RNAs under different replication modes.

ABSTRACT: Evolutionary and dynamical investigations into real viral populations indicate that RNA replication can range between the two extremes represented by so-called 'stamping machine replication' (SMR) and 'geometric replication' (GR). The impact of asymmetries in replication for single-stranded (+) sense RNA viruses has been mainly studied with deterministic models. However, viral replication should be better described by including stochasticity, as the cell infection process is typically initiated with a very small number of RNA macromolecules, and thus largely influenced by intrinsic noise. Under appropriate conditions, deterministic theoretical descriptions of viral RNA replication predict a quasi-neutral coexistence scenario, with a line of fixed points involving different strands' equilib

SUBMITTER: Sardanyes J 

PROVIDER: S-EPMC6000170 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature