Modelling the metabolism of protein secretion through the Tat route in Streptomyces lividans.

ABSTRACT:

Background

Streptomyces lividans has demonstrated its value as an efficient host for protein production due to its ability to secrete functional proteins directly to the media. Secretory proteins that use the major Sec route need to be properly folded outside the cell, whereas secretory proteins using the Tat route appear outside the cell correctly folded. This feature makes the Tat system very attractive for the production of natural or engineered Tat secretory proteins. S. lividans cells are known to respond differently to overproduction and secretion of Tat versus Sec proteins. Increased understanding of the impact of protein secretion through the Tat route can be obtained by a deeper analysis of the metabolic impact associated with protein production, and its dependence on prot

SUBMITTER: Valverde JR 

PROVIDER: S-EPMC6000921 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature