Intrachromosomal colocalization strengthens co-expression, co-modification and evolutionary conservation of neighboring genes.

ABSTRACT:

Background

Gene order and location in chromosomes of species are non-random. Neighboring gene pairs tend to display some similarities, such as co-expression and co-modification. However, the contribution of linear proximity, spatial proximity, and evolutionary proximity to these similarities remain unclear, together with whether the presence of several types of proximity can strengthens the similarities.

Results

In this study, we investigated the properties of three kinds of colocalized gene pairs: intrachromosomal colocalized gene pairs, always-neighboring gene pairs, and evolutionary neighboring gene pairs. Our analysis showed that (1) Different types of colocalized genes differentially contribute to co-expression, co-modifications and conservation across species; (2) Intr

SUBMITTER: Lian S 

PROVIDER: S-EPMC6000932 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature