Cell type-specific analysis of transcriptome changes in the porcine endometrium on Day 12 of pregnancy.

ABSTRACT:

Background

Along with trophoblast elongation (Days 10 to 12), estradiol is secreted in increasing amounts for recognition of pregnancy. Endometrial secretions driven by ovarian progesterone and conceptus signals are essential for conceptus growth and development. Results of transcriptome analyses of whole endometrial tissue samples in the pig indicated the need for cell type-specific endometrial gene expression analysis for a better understanding of transcriptome changes associated with establishment of pregnancy.

Results

The most distinct transcriptome profile and the majority of differentially expressed genes (DEGs) were identified in luminal epithelium (LE). Many DEGs were found only in the cell type-specific analysis. The functional classification of DEGs identified in s

SUBMITTER: Zeng S 

PROVIDER: S-EPMC6000939 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature