NDRG1 regulates neutral lipid metabolism in breast cancer cells.

ABSTRACT:

Background

Altered lipid metabolism is an emerging hallmark of aggressive breast cancers. The N-myc downstream regulated gene (NDRG1) gene plays a critical role in peripheral nervous system myelination, as inactivating mutations cause severe demyelinating neuropathy. In breast cancer, elevated NDRG1 expression has been linked to clinical outcomes, but its functional role in breast cancer physiology has remained unclear.

Methods

A meta-analysis of NDRG1 expression in multiple large publicly available genomic databases was conducted. Genome-wide expression correlation and Cox proportional hazards and Kaplan-Meier modeling of clinical outcomes associated with elevated expression were assessed. To study NDRG1 function, gene silencing and overexpression phenotypic studies were ca

SUBMITTER: Sevinsky CJ 

PROVIDER: S-EPMC6001025 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature