Mutational Signatures in Cancer (MuSiCa): a web application to implement mutational signatures analysis in cancer samples.

ABSTRACT: BACKGROUND:Mutational signatures have been proved as a valuable pattern in somatic genomics, mainly regarding cancer, with a potential application as a biomarker in clinical practice. Up to now, several bioinformatic packages to address this topic have been developed in different languages/platforms. MutationalPatterns has arisen as the most efficient tool for the comparison with the signatures currently reported in the Catalogue of Somatic Mutations in Cancer (COSMIC) database. However, the analysis of mutational signatures is nowadays restricted to a small community of bioinformatic experts. RESULTS:In this work we present Mutational Signatures in Cancer (MuSiCa), a new web tool based on MutationalPatterns and built using the Shiny framework in R language. By means of a simple interface

SUBMITTER: Diaz-Gay M 

PROVIDER: S-EPMC6001047 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature