KLRD1-expressing natural killer cells predict influenza susceptibility.

ABSTRACT:

Background

Influenza infects tens of millions of people every year in the USA. Other than notable risk groups, such as children and the elderly, it is difficult to predict what subpopulations are at higher risk of infection. Viral challenge studies, where healthy human volunteers are inoculated with live influenza virus, provide a unique opportunity to study infection susceptibility. Biomarkers predicting influenza susceptibility would be useful for identifying risk groups and designing vaccines.

Methods

We applied cell mixture deconvolution to estimate immune cell proportions from whole blood transcriptome data in four independent influenza challenge studies. We compared immune cell proportions in the blood between symptomatic shedders and asymptomatic nonshedders across th

SUBMITTER: Bongen E 

PROVIDER: S-EPMC6001128 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature