Non-invasive high-frequency oscillatory ventilation versus nasal continuous positive airway pressure in preterm infants with respiratory distress syndrome: Study protocol for a multi-center prospective randomized controlled trial.

ABSTRACT:

Background

Invasive mechanical ventilation (IMV) is associated with the development of adverse pulmonary and non-pulmonary outcomes in very premature infants. Various modes of non-invasive respiratory support are increasingly being used to decrease the incidence of bronchopulmonary dysplasia. The aim of this trial is to compare the effect of non-invasive high-frequency oscillatory ventilation (NHFOV) and nasal continuous positive airway pressure (NCPAP) in preterm infants with respiratory distress syndrome (RDS) as a primary non-invasive ventilation support mode.

Methods/design

In this multi-center randomized controlled trial, 300 preterm infants born at a gestational age of 26^6/7 to 33^6/7 weeks with a diagnosis of RDS will be randomized to NHFOV or NCP

SUBMITTER: Zhu XW 

PROVIDER: S-EPMC6001134 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature