OSM potentiates preintravasation events, increases CTC counts, and promotes breast cancer metastasis to the lung.

ABSTRACT: BACKGROUND:Systemic and chronic inflammatory conditions in patients with breast cancer have been associated with reduced patient survival and increased breast cancer aggressiveness. This paper characterizes the role of an inflammatory cytokine, oncostatin M (OSM), in the preintravasation aspects of breast cancer metastasis. METHODS:OSM expression levels in human breast cancer tissue samples were assessed using tissue microarrays, and expression patterns based on clinical stage were assessed. To determine the in vivo role of OSM in breast cancer metastasis to the lung, we used three orthotopic breast cancer mouse models, including a syngeneic 4T1.2 mouse mammary cancer model, the MDA-MB-231 human breast cancer xenograft model, and an OSM-knockout (OSM-KO) mouse model. Progression of metasta

SUBMITTER: Tawara K 

PROVIDER: S-EPMC6001163 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature