Carboxylate-directed C-H allylation with allyl alcohols or ethers.

ABSTRACT: A [Ru(p-cymene)Cl₂]₂ catalyst activates allyl alcohols and ethers for the regioselective ortho-C-H allylation of aromatic and heteroaromatic carboxylates. The reaction is orthogonal to most C-H functionalisations with allyl alcohols in that allyl arenes rather than carbonyl compounds are obtained. A wide range of substrates are thus smoothly transformed to allylarenes at 50 °C in phosphate-buffered 2,2,2-trichloroethanol. The reaction concept combines the use of abundant reagents and directing groups in a sustainable, waste-minimised method for C-C bond formation.

SUBMITTER: Hu XQ 

PROVIDER: S-EPMC6001406 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature