Differential Expression of CircRNAs in Embryonic Heart Tissue Associated with Ventricular Septal Defect.

ABSTRACT: Objectives: To explore and validate the differential expression of circRNAs in the myocardium of congenital ventricular septal defect (VSD) and to explore a new avenue of research regarding the pathological mechanisms of VSD. Methods: We detected circRNAs expression profiles in heart tissues taken from six aborted fetuses with VSD and normal group using circRNA microarray. Some differentially expressed circRNAs were studied by bioinformatics analysis. Finally, quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed to confirm these results. Results: This study found abundant circRNAs in the myocardium taken from individuals in the normal group and the VSD group. After that, totally 6234 differentially expressed circRNAs between the normal g

SUBMITTER: Liu H 

PROVIDER: S-EPMC6001411 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature