Propofol attenuates osteoclastogenesis by lowering RANKL/OPG ratio in mouse osteoblasts.

ABSTRACT: Bone remodeling plays an important role in the bone healing process; for example, following fracture. The relative ratio of the receptor activator of nuclear factor kappa B ligand (RANKL)/ osteoprotegerin (OPG) controls osteoclast differentiation, thereby playing a pivotal role in the regulation of bone remodeling. Propofol, a widely used anesthetic agent in orthopedic procedures, is considered to possess potential antioxidant properties owing to its structural similarity to α-tocopherol. Antioxidants are known to enhance bone healing. Accordingly, in the present study, we aimed to investigate osteoblastic differentiation and RANKL/OPG expression following propofol administration, in order to assess the potentially beneficial effects of this drug on the bone remodeling process, using calva

SUBMITTER: Lee DW 

PROVIDER: S-EPMC6001417 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature