A simple hand-held magnet array for efficient and reproducible SABRE hyperpolarisation using manual sample shaking.

ABSTRACT: Signal amplification by reversible exchange (SABRE) is a hyperpolarisation technique that catalytically transfers nuclear polarisation from parahydrogen, the singlet nuclear isomer of H₂ , to a substrate in solution. The SABRE exchange reaction is carried out in a polarisation transfer field (PTF) of tens of gauss before transfer to a stronger magnetic field for nuclear magnetic resonance (NMR) detection. In the simplest implementation, polarisation transfer is achieved by shaking the sample in the stray field of a superconducting NMR magnet. Although convenient, this method suffers from limited reproducibility and cannot be used with NMR spectrometers that do not have appreciable stray fields, such as benchtop instruments. Here, we use a simple hand-held permanent magnet array

SUBMITTER: Richardson PM 

PROVIDER: S-EPMC6001426 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature