Association of GPIa and COX-2 gene polymorphism with aspirin resistance.

ABSTRACT:

Objective

This study aimed to explore the association between GPIa, COX-2 gene polymorphisms and aspirin resistance in the ischemic stroke patients from the southern part of Jiangsu province.

Methods

In all, 97 patients with acute ischemic stroke were enrolled in the study. GPIa gene polymorphism at 807C>T (rsl126643) locus and COX-2 gene polymorphism at -765G>C (rs20417) locus were genotyped by PCR pyrosequencing technology. Patients were divided into the aspirin sensitivity (AS) group and aspirin resistance (AR) group according to the platelet aggregation rate. The relationship between the two gene polymorphisms and aspirin resistance was investigated and analyzed.

Results

The distribution of the genotype (CC, CT, TT, CT + TT, and CC) and the frequency of allele T o

SUBMITTER: Wang H 

PROVIDER: S-EPMC6001439 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature