Effects of endovascular cooling on infarct size in ST-segment elevation myocardial infarction: A patient-level pooled analysis from randomized trials.

ABSTRACT:

Objectives

This study sought to examine the relationship between temperature at reperfusion and infarct size.

Background

Hypothermia consistently reduces infarct size when administered prior to reperfusion in animal studies, however, clinical results have been inconsistent.

Methods

We performed a patient-level pooled analysis from six randomized control trials of endovascular cooling during primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) in 629 patients in which infarct size was assessed within 1 month after randomization by either single-photon emission computed tomography (SPECT) or cardiac magnetic resonance imaging (cMR).

Results

In anterior infarct patients, after controlling for variability between s

SUBMITTER: Dae M 

PROVIDER: S-EPMC6001463 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature