Associations Between Polypharmacy and Cognitive and Physical Capability: A British Birth Cohort Study.

ABSTRACT:

Objectives

To investigate longitudinal associations between polypharmacy and cognitive and physical capability and to determine whether these associations differ with cumulative exposure to polypharmacy.

Design

Prospective birth cohort study.

Setting

England, Scotland, and Wales.

Participants

An eligible sample of men and women from the Medical Research Council National Survey of Health and Development with medication data at age 69 (N=2,122, 79%).

Measurements

Cognitive capability was assessed using a word learning test, visual search speed task, and the Addenbrooke's Cognitive Examination, Third Edition (ACE-III). Physical capability was measured using chair rise speed, standing balance time, walking speed, and grip strength.

Results

Polypharmac

SUBMITTER: Rawle MJ 

PROVIDER: S-EPMC6001617 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature