Explained variation of excess hazard models.

ABSTRACT: The availability of longstanding collection of detailed cancer patient information makes multivariable modelling of cancer-specific hazard of death appealing. We propose to report variation in survival explained by each variable that constitutes these models. We adapted the ranks explained (RE) measure to the relative survival data setting, ie, when competing risks of death are accounted for through life tables from the general population. RE is calculated at each event time. We introduce weights for each death reflecting its probability to be a cancer death. RE varies between -1 and +1 and can be reported at given times in the follow-up and as a time-varying measure from diagnosis onward. We present an application for patients diagnosed with colon or lung cancer in England. The RE measure

SUBMITTER: Maringe C 

PROVIDER: S-EPMC6001643 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature