How should minimally important change scores for the Patient-Oriented Eczema Measure be interpreted? A validation using varied methods.

ABSTRACT:

Background

The Patient-Oriented Eczema Measure (POEM), scored 0-28, is the core outcome instrument recommended for measuring patient-reported atopic eczema symptoms in clinical trials. To date, two published studies have broadly concurred that the minimally important change (MIC) of the POEM is three points. Further assessment of the MIC of POEM in different populations, and using a variety of methods, will improve interpretability of the POEM in research and clinical practice.

Objectives

To calculate the smallest detectable change in the POEM and estimate the MIC of the POEM using a variety of methods in a trial dataset of children with moderate-to-severe atopic eczema.

Methods

This study used distribution-based and anchor-based methods to calculate the MIC of the PO

SUBMITTER: Howells L 

PROVIDER: S-EPMC6001667 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature