Ra-224 labeling of calcium carbonate microparticles for internal α-therapy: Preparation, stability, and biodistribution in mice.

ABSTRACT: Internal therapy with α-emitters should be well suited for micrometastatic disease. Radium-224 emits multiple α-particles through its decay and has a convenient 3.6 days of half-life. Despite its attractive properties, the use of ²²⁴ Ra has been limited to bone-seeking applications because it cannot be stably bound to a targeting molecule. Alternative delivery systems for ²²⁴ Ra are therefore of considerable interest. In this study, calcium carbonate microparticles are proposed as carriers for ²²⁴ Ra, designed for local therapy of disseminated cancers in cavitary regions, such as peritoneal carcinomatosis. Calcium carbonate microparticles were radiolabeled by precipitation of ²²⁴ Ra on the particle surface, resulting in high labeling efficiencies

SUBMITTER: Westrom S 

PROVIDER: S-EPMC6001669 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature