Genetic polymorphisms in the TERT gene and susceptibility to non-small cell lung cancer in a Chinese Han population.

ABSTRACT:

Background

Recent studies have revealed that the TERT gene plays crucial roles in cancer initiation and development. Genome-wide analysis studies and case-control studies have demonstrated that polymorphisms in the TERT gene are associated with various cancers.

Materials and methods

In the current study, we analyzed the associations of eight single nucleotide polymorphisms (SNPs) in the TERT gene with non-small cell lung cancer (NSCLC) in a Chinese Han population. A total of 467 NSCLC patients and 526 healthy individuals were recruited for SNP genotyping using a TaqMan assay.

Results

Our results revealed that the allelic frequencies of rs2853677 and rs2853691 were significantly different between the NSCLC and control groups (P=0.004 and 0.0

SUBMITTER: Li C 

PROVIDER: S-EPMC6001840 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature