Plasma Sphingolipids are Associated With Gait Parameters in the Mayo Clinic Study of Aging.

ABSTRACT:

Background

Disrupted gait has been associated with an increased risk of frailty, disability, and death, but the causal molecular pathways are not well understood. Sphingolipids, including ceramides, are associated with multiple age-related diseases. Ceramides promote atrophy, necrosis, and proteolysis in cellular and animal models, and ceramide C16:0 levels are negatively correlated with muscle mass in men. However, there is a paucity of evidence examining sphingolipids and physical function.

Methods

We examined the cross-sectional association between plasma ceramides, sphingosine-1-phosphate (S1P), and ceramide/S1P ratios and gait, a robust measure of physical function, in 340 clinically normal participants aged 70 years and older enrolled in the Mayo Clinic Study of Aging.

SUBMITTER: Wennberg AMV 

PROVIDER: S-EPMC6001885 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature