Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice.

ABSTRACT:

Objectives

Neuraminidase 1 (NEU1) cleaves terminal sialic acids of glycoconjugates during lysosomal catabolism. It also modulates the structure and activity of cellular surface receptors affecting diverse pathways. Previously we demonstrated that NEU1 activates the insulin receptor (IR) and that NEU1-deficient CathA^S190A-Neo mice (hypomorph of the NEU1 activator protein, cathepsin A/CathA) on a high-fat diet (HFD) develop hyperglycaemia and insulin resistance faster than wild-type animals. The major objective of the current work was to reveal the molecular mechanism by which NEU1 desialylation activates the IR and to test if increase of NEU1 activity in insulin target tissues reverses insulin resistance and glucose intolerance.

Methods

To test if desialylation cau

SUBMITTER: Fougerat A 

PROVIDER: S-EPMC6001920 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature