Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intolerance.

ABSTRACT:

Objective

Breakthroughs in HIV treatment, especially combination antiretroviral therapy (ART), have massively reduced AIDS-associated mortality. However, ART administration amplifies the risk of non-AIDS defining illnesses including obesity, diabetes, and cardiovascular disease, collectively known as metabolic syndrome. Initial reports suggest that ART-associated risk of metabolic syndrome correlates with socioeconomic status, a multifaceted finding that encompasses income, race, education, and diet. Therefore, determination of causal relationships is extremely challenging due to the complex interplay between viral infection, ART, and the many environmental factors.

Methods

In the current study, we employed a mouse model to specifically examine interactions between ART and d

SUBMITTER: Pepin ME 

PROVIDER: S-EPMC6001921 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature