Does incipient dementia explain normal cognitive decline determinants? Lothian birth cohort 1921.

ABSTRACT: The presence of an apolipoprotein E (APOE) ε4 allele, lower physical fitness, smoking, and lower serum vitamin B-12 have been reported as contributing to poorer cognitive function in LBC1921 at age 79, after adjusting for childhood intelligence. Because incident dementia was not previously ascertained within LBC1921, it is possible that preclinical or unrecognized cases at age 79 influenced findings. Dementia cases arising over approximately 16 years of follow-up were determined by a consensus using evidence from electronic medical records, death certificates, and clinical reviews. The analyses from the original reports were repeated after the exclusion of those who had developed dementia. In a subsequent set of analyses, the authors considered the potential impact of terminal decline, exc

SUBMITTER: Sibbett RA 

PROVIDER: S-EPMC6001941 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature