Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice.

ABSTRACT: Liver cancer comprises a group of malignant tumors, among which hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most common. ICC is especially pernicious and associated with poor clinical outcome. Studies have shown that a subset of human ICCs may originate from mature hepatocytes. However, the mechanisms driving the trans-differentiation of hepatocytes into malignant cholangiocytes remain poorly defined. We adopted lineage tracing techniques and an established murine hepatocyte-derived ICC model by hydrodynamic injection of activated forms of AKT (myr-AKT) and Yap (YapS127A) proto-oncogenes. Wild-type, Notch1 ^flox/flox , and Notch2 ^flox/flox mice were used to investigate the role of canonical Notch signaling and Notch receptors in AKT

SUBMITTER: Wang J 

PROVIDER: S-EPMC6002343 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature