Chimeric HCMV/HSV-1 and Δγ₁34.5 oncolytic herpes simplex virus elicit immune mediated antigliomal effect and antitumor memory.

ABSTRACT: Malignant gliomas are the most common primary brain tumor and are characterized by rapid and highly invasive growth. Because of their poor prognosis, new therapeutic strategies are needed. Oncolytic virotherapy (OV) is a promising strategy for treating cancer that incorporates both direct viral replication mediated and immune mediated mechanisms to kill tumor cells. C134 is a next generation Δγ₁34.5 oHSV-1 with improved intratumoral viral replication. It remains safe in the CNS environment by inducing early IFN signaling which restricts its replication in non-malignant cells. We sought to identify how C134 performed in an immunocompetent tumor model that restricts its replication advantage over first generation viruses. To achieve this we identified tumors that have intact IFN s

SUBMITTER: Ghonime MG 

PROVIDER: S-EPMC6002352 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature