Ontology highlight
ABSTRACT:
SUBMITTER: Pereira ER
PROVIDER: S-EPMC6002772 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20180322 6382
Lymph node metastases in cancer patients are associated with tumor aggressiveness, poorer prognoses, and the recommendation for systemic therapy. Whether cancer cells in lymph nodes can seed distant metastases has been a subject of considerable debate. We studied mice implanted with cancer cells (mammary carcinoma, squamous cell carcinoma, or melanoma) expressing the photoconvertible protein Dendra2. This technology allowed us to selectively photoconvert metastatic cells in the lymph node and tr ...[more]