Genetic risk of APOL1 and kidney disease in children and young adults of African ancestry.

ABSTRACT: PURPOSE OF REVIEW:Understanding the genetic risk of APOL1 in children and young adults is important given the lifetime risk of hypertension and kidney disease among children of African descent. We review recent epidemiologic and biologic findings on the effects of APOL1 and kidney disease. RECENT FINDINGS:APOL1 in children and young adults is associated with hypertension, albuminuria and more rapid decline in kidney function and progression to end-stage kidney disease, especially among those with glomerular causes of kidney disease, and those affected by sickle cell disease or HIV. There are conflicting data on the APOL1 association with cardiovascular disease in children and young adults. APOL1 functions as part of the innate immune system. Podocyte expression of APOL1 likely contributes

SUBMITTER: Reidy KJ 

PROVIDER: S-EPMC6002812 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature