Crystal structures of binary compounds of meldonium 3-(1,1,1-tri-methyl-hydrazin-1-ium-2-yl)prop-ano-ate with sodium bromide and sodium iodide.

ABSTRACT: 3-(1,1,1-Tri-methyl-hydrazin-1-ium-2-yl)propano-ate (C₆H₁₄N₂O₂, M, more commonly known under its commercial names Meldonium or Mildronate) co-crystalizes with sodium bromide and sodium iodide forming polymeric hydrates poly[[tetra-μ-aqua-di-aqua-bis-[3-(1,1,1-tri-methyl-hydrazin-1-ium-2-yl)propano-ate]disodium] dibromide tetra-hydrate], [Na₂(C₆H₁₄N₂O₂)₂(H₂O)₆]Br₂·4H₂O, and poly[[di-μ-aqua-di-aqua-[μ-3-(1,1,1-tri-methyl-hydrazin-1-ium-2-yl)propano-ate]disodium] diiodide], [Na₂(C₆H₁₄N₂O₂)₂(H₂O)₄]I₂. The coordination numbers of the sodium ions are 6; the coordination polyhedra can be described as distorted octa-hedra. Metal ions and M zwitterions are assembled into infinite layers via electrostatic inter-actions and hydrogen-bonded networks. These layers are connected via electrostatic attraction between halogenide ions and positive tri-methyl-hydrazinium groups into a three-dimensional structure.

SUBMITTER: Nazarenko AY 

PROVIDER: S-EPMC6002828 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature