Increased risk of aminoglycoside-induced hearing loss in MDR-TB patients with HIV coinfection.

ABSTRACT:

Setting

A high proportion of individuals with multidrug-resistant tuberculosis (MDR-TB) develop permanent hearing loss due to ototoxicity caused by injectable aminoglycosides (AGs). The prevalence of AG-induced hearing loss is greatest in tuberculosis (TB) and human immunodeficiency virus (HIV) endemic countries in sub-Saharan Africa. However, whether HIV coinfection is associated with a higher incidence of AG-induced hearing loss during MDR-TB treatment is controversial.

Objective

To evaluate the impact of HIV coinfection on AG-induced hearing loss among individuals with MDR-TB in sub-Saharan Africa.

Design

This was a meta-analysis of articles published in PubMed, Embase, Scopus, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Cochrane Revie

SUBMITTER: Hong H 

PROVIDER: S-EPMC6002855 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature