Metabolically Healthy Obesity, Transition to Metabolic Syndrome, and Cardiovascular Risk.

ABSTRACT:

Background

Debate over the cardiometabolic risk associated with metabolically healthy obesity (MHO) continues. Many studies have investigated this relationship by examining MHO at baseline with longitudinal follow-up, with inconsistent results.

Objectives

The authors hypothesized that MHO at baseline is transient and that transition to metabolic syndrome (MetS) and duration of MetS explains heterogeneity in incident cardiovascular disease (CVD) and all-cause mortality.

Methods

Among 6,809 participants of the MESA (Multi-Ethnic Study of Atherosclerosis) the authors used Cox proportional hazards and logistic regression models to investigate the joint association of obesity (≥30 kg/m²) and MetS (International Diabetes Federation consensus definition) with CVD

SUBMITTER: Mongraw-Chaffin M 

PROVIDER: S-EPMC6002856 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature