In vitro to in vivo benchmark dose comparisons to inform risk assessment of quantum dot nanomaterials.

ABSTRACT: Engineered nanomaterials are currently under review for their potential toxicity; however, their use in consumer/commercial products has continued to outpace risk assessments. In vitro methods may be utilized as tools to improve the efficiency of risk assessment approaches. We propose a framework to compare relationships between previously published in vitro and in vivo toxicity assessments of cadmium-selenium containing quantum dots (QDs) using benchmark dose (BMD) and dosimetric assessment methods. Although data were limited this approach was useful for identifying sensitive assays and strains. In vitro studies assessed effects of QDs in three pulmonary cell types across two mouse strains. Significant dose-response effects were modeled and a standardized method of BMD analysis was perfor

SUBMITTER: Weldon BA 

PROVIDER: S-EPMC6002898 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature