Genetic, laboratory and clinical risk factors in the development of overt ischemic stroke in children with sickle cell disease.

ABSTRACT: Cerebrovascular disease, particularly stroke, is one of the most severe clinical complications associated with sickle cell disease and is a significant cause of morbidity in both children and adults. Over the past two decades, considerable advances have been made in the understanding of its natural history and enabled early identification and treatment of children at the highest risk. Transcranial Doppler screening and regular blood transfusions have markedly reduced the risk of stroke in children. However, transcranial Doppler has a limited positive predictive value and the pathophysiology of cerebrovascular disease is not completely understood. In this review, we will focus on the current state of knowledge about risk factors associated with ischemic stroke in patients with sickle cell d

SUBMITTER: Belisario AR 

PROVIDER: S-EPMC6003005 | biostudies-literature | 2018 Apr-Jun

REPOSITORIES: biostudies-literature