A rare CHD5 haplotype and its interactions with environmental factors predicting hepatocellular carcinoma risk.

ABSTRACT:

Background

CHD5 is a conventional tumour-suppressing gene in many tumours. The aim of this study was to determine whether CHD5 variants contribute to the risk of hepatocellular carcinoma (HCC).

Methods

Gene variants were identified using next-generation sequencing targeted on referenced mutations followed by TaqMan genotyping in two case-control studies.

Results

We discovered a rare variant (haplotype AG) in CHD5 (rs12564469-rs9434711) that was markedly associated with the risk of HCC in a Chinese population. A logistical regression model and permutation test confirmed the association. Indeed, the association quality increased in a gene dose-dependent manner as the number of samples increased. In the stratified analysis, this haplotype risk effect was statistically si

SUBMITTER: Xiao Q 

PROVIDER: S-EPMC6003142 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature