Novel anti-obesity effects of beer hops compound xanthohumol: role of AMPK signaling pathway.

ABSTRACT:

Background

Obesity alters adipose tissue metabolic and endocrine functioning, leading to an increased adiposity and release of pro-inflammatory cytokines. Various phytochemicals have been reported to contribute to the beiging of white adipose tissue in order to ameliorate obesity by increasing thermogenesis. Here, we show that the prenylated chalcone, xanthohumol (XN), induces beiging of white adipocytes, stimulates lipolysis, and inhibits adipogenesis of murine 3T3-L1 adipocytes and primary human subcutaneous preadipocytes and these effects are partly mediated by the activation of the AMP-activated protein kinase (AMPK) signaling pathway.

Methods

3T3-L1 adipocytes and primary human subcutaneous preadipocytes were differentiated using a standard protocol and were treated wit

SUBMITTER: Samuels JS 

PROVIDER: S-EPMC6003190 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature