Steroid signaling mediates nutritional regulation of juvenile body growth via IGF-binding protein in Drosophila.

ABSTRACT: Nutritional condition during the juvenile growth period considerably affects final adult size. The insulin/insulin-like growth factor signaling (IIS)/target of rapamycin (TOR) nutrient-sensing pathway is known to regulate growth and metabolism in response to nutritional conditions. However, there is limited information on how endocrine pathways communicate nutritional information to different metabolic organs to regulate organismal growth. Here, we show that Imaginal morphogenesis protein-Late 2 (Imp-L2), a Drosophila homolog of insulin-like growth factor-binding protein 7 (IGFBP7), plays a key role in the nutritional control of organismal growth. Nutritional restriction during the larval growth period causes undersized adults, which is largely diminished by Imp-L2 mutation.

SUBMITTER: Lee GJ 

PROVIDER: S-EPMC6003328 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature