Impact of lower uterine segment involvement in type II endometrial cancer and the unique mutational profile of serous tumors.

ABSTRACT:

Objective

Evaluation of the impact of lower uterine segment involvement (LUSI) in type II endometrial cancer, and mutational profile of uterine papillary serous carcinomas (UPSC).

Methods

Retrospective cohort study comparing patients with type II endometrial cancer with LUSI to patients without LUSI. Genes commonly implicated in carcinogenesis were analyzed in a subgroup of 42 patients with UPSC using next generation sequencing.

Results

83 patients with type II endometrial cancer were included in the study, of these, LUSI was diagnosed in 31.3%. During a median follow-up of 45.5 months, patients with LUSI developed more local and distant recurrences (local: 19.2% vs. 3.5%, P = .03; distant: 50% vs. 17.5%, P = .004) and progression events (73.1% vs. 26.3%

SUBMITTER: Kogan L 

PROVIDER: S-EPMC6003406 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature