Linked genetic variation and not genome structure causes widespread differential expression associated with chromosomal inversions.

ABSTRACT: Chromosomal inversions are widely thought to be favored by natural selection because they suppress recombination between alleles that have higher fitness on the same genetic background or in similar environments. Nonetheless, few selected alleles have been characterized at the molecular level. Gene expression profiling provides a powerful way to identify functionally important variation associated with inversions and suggests candidate phenotypes. However, altered genome structure itself might also impact gene expression by influencing expression profiles of the genes proximal to inversion breakpoint regions or by modifying expression patterns genome-wide due to rearranging large regulatory domains. In natural inversions, genetic differentiation and genome structure are inextricably linked

SUBMITTER: Said I 

PROVIDER: S-EPMC6003460 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature