Transcriptomic context of <i>DRD1</i> is associated with prefrontal activity and behavior during working memory.

ABSTRACT: Dopamine D₁ receptor (D₁R) signaling shapes prefrontal cortex (PFC) activity during working memory (WM). Previous reports found higher WM performance associated with alleles linked to greater expression of the gene coding for D₁Rs (DRD1). However, there is no evidence on the relationship between genetic modulation of DRD1 expression in PFC and patterns of prefrontal activity during WM. Furthermore, previous studies have not considered that D₁Rs are part of a coregulated molecular environment, which may contribute to D₁R-related prefrontal WM processing. Thus, we hypothesized a reciprocal link between a coregulated (i.e., coexpressed) molecular network including DRD1 and PFC activity. To explore this relationship, w

SUBMITTER: Fazio L 

PROVIDER: S-EPMC6003490 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature