Physics of lumen growth.

ABSTRACT: We model the dynamics of formation of intercellular secretory lumens. Using conservation laws, we quantitatively study the balance between paracellular leaks and the build-up of osmotic pressure in the lumen. Our model predicts a critical pumping threshold to expand stable lumens. Consistently with experimental observations in bile canaliculi, the model also describes a transition between a monotonous and oscillatory regime during luminogenesis as a function of ion and water transport parameters. We finally discuss the possible importance of regulation of paracellular leaks in intercellular tubulogenesis.

SUBMITTER: Dasgupta S 

PROVIDER: S-EPMC6003502 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature