High mobility group A2 (HMGA2) deficiency in pigs leads to dwarfism, abnormal fetal resource allocation, and cryptorchidism.

ABSTRACT: Expression of HMGA2 is strongly associated with body size and growth in mice and humans. In mice, inactivation of one or both alleles of Hmga2 results in body-size reductions of 20% and 60%, respectively. In humans, microdeletions involving the HMGA2 locus result in short stature, suggesting the function of the HMGA2 protein is conserved among mammals. To test this hypothesis, we generated HMGA2-deficient pigs via gene editing and somatic cell nuclear transfer (SCNT). Examination of growth parameters revealed that HMGA2^-/+ male and female pigs were on average 20% lighter and smaller than HMGA2^+/+ matched controls (P < 0.05). HMGA2^-/- boars showed significant size reduction ranging from 35 to 85% of controls d

SUBMITTER: Chung J 

PROVIDER: S-EPMC6003518 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature