Overexpression of topoisomerase II alpha protein is a factor for poor prognosis in patients with luminal B breast cancer.

ABSTRACT:

Background

The prognostic value and the best method of testing of topoisomerase II alpha (TOP2A) status have not been established in modern tailored therapy based on breast cancer subtype.

Results

The frequencies of TOP2A overexpression and TOP2A amplified were 55.8% and 9.5%, respectively. TOP2A overexpression correlated strongly with non-luminal A subtype (χ²-test, p < 0.001). TOP2A overexpression was significantly associated with relapse-free survival in luminal B breast cancer (n = 316; log rank test, p < 0.001) but not in other breast cancer subtypes. Cox regression analysis showed that TOP2A overexpression is a significant prognostic factor in luminal B breast cancer (hazard ratio (HR) 4.00, 95% confidence interval (CI) 1.65-9.54,

SUBMITTER: Shigematsu H 

PROVIDER: S-EPMC6003555 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature